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- At Significantly Higher Risk
- • Advancing age, usually over age 40.
- • Family history of colorectal cancer, especially among first-degree relatives (Lynch syndrome Type I). The risk
- is two to three times the risk of an average person.
- • "Cancer Family Syndrome" (Lynch syndrome Type II), with a higher risk for colon cancer and other
- adenocarcinomas such as cancers of the ovary, endometrium, breast and pancreas.
- • A personal or family history of multiple adenomatous polyps after age 10 (familial polyposis).
- • Previous polyps of the colon and rectum.
- • Inflammatory bowel disease such as ulcerative colitis and ileitis (Crohn's disease). With ulcerative colitis, the
- risk of cancer is about 20 times the average. Cancer may also develop in the flat surface of the mucosa rather
- than in polyps. Increased risk for ulcerative colitis occurs in gynecologic cancer, prostate or pelvic cancer, and
- pelvic cancer following radiation therapy .
- • Diets high in fat and low in fiber and calcium . Animal rather than vegetable fat is believed responsible. One
- study indicated that women eating red meat (beef, lamb and pork) daily had 2 1/2 times the risk of those who
- eat red meat less than once a month. Those eating fish and chicken without the skin were at lesser risk.
- • High consumption of charcoal-broiled foods.
- • Inactivity and constipation.
- • Asbestos exposure.
- • European (Ashkenazy) Jews.
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